题目：Control of Molecular Purity, Crystal Structure, and Particle Size Distribution in Pharmaceutical Crystallization
时间：2014.6.30 上午8:30-10:30
地点：逸夫会议中心中心会议室
报告人：Richard D. Braatz
摘要: An overview is provided on advances in the control of molecular purity, crystal structure, and particle size distribution of pharmaceutical crystals. A nonlinear feedback control strategy is described that is robust to orders-of-magnitude variations in the crystallization kinetics, which enables the same feedback controller to apply to completely different pharmaceutical compounds by just updating the drug solubility. The control strategy enables the manufacture of large drug crystals of uniform size and specified crystal structure, regardless of whether the crystal structure is thermodynamically stable or metastable. The control strategy forces the closed-loop operations to be within a tightly constrained trajectory bundle that connects the initial states to the desired final states. A modification of the methodology is able to achieve a target crystal size distribution by employing continual manipulation of seeds manufactured using a dual-impinging jet mixer. The methodology has been evaluated in theoretical, simulation, and experimental studies for a wide variety of pharmaceutical compounds. The presentation ends with a discussion of directions towards the simultaneous control of multiple properties, by the integration of feedback control with process design.
报告人简介:Richard D. Braatz is the Edwin R. Gilliland Professor at the Massachusetts Institute of Technology (MIT) where he does research in control theory and its application to biomedical systems, pharmaceuticals manufacturing, and nanotechnology. He received MS and PhD degrees from the California Institute of Technology and was a Professor at the University of Illinois at Urbana-Champaign and a Visiting Scholar at Harvard University before moving to MIT. He has consulted or collaborated with more than a dozen companies including IBM, United Technologies Corporation, Novartis, and Abbott Laboratories. Honors include the AACC Donald P. Eckman Award, the ASEE Curtis W. McGraw Research Award, the AIChE Excellence in Process Development Research Award, and IEEE Control Systems Society Transition to Practice Award. He is a Fellow of IEEE, IFAC, and the American Association for the Advancement of Science.
